{"id":847,"date":"2022-04-30T13:35:53","date_gmt":"2022-04-30T12:35:53","guid":{"rendered":"https:\/\/rdu.if.ua\/?p=847"},"modified":"2022-09-17T13:53:50","modified_gmt":"2022-09-17T12:53:50","slug":"mimicking-caloric-restriction-for-anti-aging-effects-the-pro-oxidant-role-of-alpha-ketoglutarate","status":"publish","type":"post","link":"https:\/\/rdu.if.ua\/en\/mimicking-caloric-restriction-for-anti-aging-effects-the-pro-oxidant-role-of-alpha-ketoglutarate\/","title":{"rendered":"Mimicking caloric restriction for anti-aging effects: The pro-oxidant role of alpha-ketoglutarate"},"content":{"rendered":"[vc_row type=”in_container” full_screen_row_position=”middle” column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” scene_position=”center” text_color=”dark” text_align=”left” row_border_radius=”none” row_border_radius_applies=”bg” overflow=”visible” overlay_strength=”0.3″ gradient_direction=”left_to_right” shape_divider_position=”bottom” bg_image_animation=”none”][vc_column column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_spacing=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”default” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” tablet_text_alignment=”default” phone_text_alignment=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][vc_column_text css=”.vc_custom_1651694788785{padding-bottom: 3% !important;}”]\"\"
\nRecent studies have shown that alpha-ketoglutarate (AKG), an important cellular intermediate, prolongs lifespan and delays the onset of age-related decline in a dose-dependent manner in several model organisms such as nematodes, fruit flies, yeasts and mice. Mimicking a state of caloric restriction and acting as a hormesis-inducing agent are proposed to be possible mechanisms underlying lifespan-extending effects of dietary AKG. Here, we analyze potential molecular mechanisms by which AKG can imitate a state of caloric restriction and stimulate production of <\/span>reactive oxygen species<\/span><\/a> (ROS) in mitochondria. According to <\/span>hormesis<\/span><\/a>, moderate increase in ROS levels induces defensive mechanisms resulting in biologically beneficial effects, such as healthier and longer lifespan. Herewith, a strong <\/span>oxidative stress<\/span><\/a> by high AKG concentrations may be responsible for lifespan-shortening effects of this metabolite. Limitations of dietary restriction hypothesis as a mechanism of AKG action are also discussed.<\/span>[\/vc_column_text][nectar_btn size=”large” open_new_tab=”true” button_style=”see-through” button_color_2=”Accent-Color” color_override=”#2954aa” icon_family=”default_arrow” text=”Read the full article” url=”https:\/\/doi.org\/10.1016\/j.cotox.2022.02.012″][\/vc_column][\/vc_row]\n","protected":false},"excerpt":{"rendered":"

Recent studies have shown that alpha-ketoglutarate (AKG), an important cellular intermediate, prolongs lifespan and delays the onset of age-related decline in a dose-dependent manner in several model organisms such as nematodes, fruit flies, yeasts and mice.<\/p>\n","protected":false},"author":1,"featured_media":1137,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"footnotes":""},"categories":[17],"tags":[],"class_list":["post-847","post","type-post","status-publish","format-standard","has-post-thumbnail","category-researches-en"],"_links":{"self":[{"href":"https:\/\/rdu.if.ua\/en\/wp-json\/wp\/v2\/posts\/847","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/rdu.if.ua\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/rdu.if.ua\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/rdu.if.ua\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/rdu.if.ua\/en\/wp-json\/wp\/v2\/comments?post=847"}],"version-history":[{"count":3,"href":"https:\/\/rdu.if.ua\/en\/wp-json\/wp\/v2\/posts\/847\/revisions"}],"predecessor-version":[{"id":953,"href":"https:\/\/rdu.if.ua\/en\/wp-json\/wp\/v2\/posts\/847\/revisions\/953"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/rdu.if.ua\/en\/wp-json\/wp\/v2\/media\/1137"}],"wp:attachment":[{"href":"https:\/\/rdu.if.ua\/en\/wp-json\/wp\/v2\/media?parent=847"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/rdu.if.ua\/en\/wp-json\/wp\/v2\/categories?post=847"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/rdu.if.ua\/en\/wp-json\/wp\/v2\/tags?post=847"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}